Polímeros: Ciência e Tecnologia
https://revistapolimeros.org.br/article/doi/10.1590/0104-1428.20240116
Polímeros: Ciência e Tecnologia
Review Article

Fibrous scaffolds for tissue engineering: from conceptualization to implementation

Thais Sayuri Iguma; Vitor Andrade Nascimento; Luciana Pastena Giorno; Sônia Maria Malmonge; Arnaldo Rodrigues Santos Jr.

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Abstract

To reduce reliance on transplants in cases of disease or trauma caused by accidents, biotechnologies in regenerative medicine and tissue engineering have emerged. The primary goal of tissue engineering is to fabricate devices that mimic the extracellular matrix of injured tissues, thereby facilitating their repair. The synthetic polymer poly(ε-caprolactone) (PCL) is recognized for its favorable mechanical properties, including load-bearing capacity, biocompatibility, and controllable biodegradability. Gelatin, derived from collagen, can replicate the natural extracellular matrix and is rich in amino acids that promote cell adhesion, proliferation, and differentiation, all of which contribute to tissue repair. This study aims to review the fabrication of fibrous scaffolds for tissue engineering, covering process from biomaterial conception to production and application. Conceptual challenges are discussed using gelatin as an example of a natural polymer and PCL as an example of a synthetic polymer.

 

 

Keywords

biotechnology, gelatin, poly (ε-caprolactone), regenerative medicine, spinning techniques

References

1 Brasil. Ministério da Saúde. (2025). Relatórios de lista de espera. Retrieved in 2025, August 13, from https://www.gov.br/saude/pt-br/composicao/saes/snt/relatorios/lista-de-espera-serie-historica

2 Santos, A. R., Jr. (2010). Bioresorbable polymers for tissue engineering. In D. Erbeli (Ed.), Tissue engineering (pp. 225-246). London: IntechOpen. https://doi.org/10.5772/8580.

3 Silva, A., Arora, S., Dhanani, S., Hornby, L., Luctkar-Flude, M., Ross-White, A., Lotherington, K., Rochon, A., Wilson, L., Latifi, M., Giorno, L., & Silva e Silva, V. (2022). Quality improvement tools to manage deceased organ donation processes: a scoping review protocol. Nurse Education in Practice, 61, 103322. https://doi.org/10.1016/j.nepr.2022.103322. PMid:35306317.

4 Sanjanwala, D., Londhe, V., Trivedi, R., Bonde, S., Sawarkar, S., Kale, V., & Patravale, V. (2024). Polysaccharide-based hydrogels for medical devices, implants and tissue engineering: a review. International Journal of Biological Macromolecules, 256(Pt 2), 128488. https://doi.org/10.1016/j.ijbiomac.2023.128488. PMid:38043653.

5 Cao, L., Su, H., Si, M., Xu, J., Chang, X., Lv, J., & Zhai, Y. (2021). Tissue engineering in stomatology: a review of potential approaches for oral disease treatments. Frontiers in Bioengineering and Biotechnology, 9, 662418. https://doi.org/10.3389/fbioe.2021.662418. PMid:34820359.

6 Marsudi, M. A., Ariski, R. T., Wibowo, A., Cooper, G., Barlian, A., Rachmantyo, R., & Bartolo, P. J. D. S. (2021). Conductive polymeric-based electroactive scaffolds for tissue engineering applications: current progress and challenges from biomaterials and manufacturing perspectives. International Journal of Molecular Sciences, 22(21), 11543. https://doi.org/10.3390/ijms222111543. PMid:34768972.

7 Baudequin, T., & Tabrizian, M. (2018). Multilineage constructs for scaffold‐based tissue engineering: a review of tissue‐specific challenges. Advanced Healthcare Materials, 7(3), 1700734. https://doi.org/10.1002/adhm.201700734. PMid:29193897.

8 Oréfice, R. L., Pereira, M. M., & Mansur, H. S. (2012). Biomateriais: fundamentos e aplicações. Rio de Janeiro: Guanabara Koogan.

9 Sun, W., Gregory, D. A., Tomeh, M. A., & Zhao, X. (2021). Silk fibroin as a functional biomaterial for tissue engineering. International Journal of Molecular Sciences, 22(3), 1499. https://doi.org/10.3390/ijms22031499. PMid:33540895.

10 Iguma, T. S., Malmonge, S. M., & Santos, A. R., Jr. (2019). Natural fibrous polymers for tissue engineering. Stem Cell and Regenerative Medicine, 3(1), 1-4. https://doi.org/10.33425/2639-9512.1037.

11 Bandzerewicz, A., & Gadomska-Gajadhur, A. (2022). Into the tissues: Extracellular matrix and its artificial substitutes: cell signalling mechanisms. Cells, 11(5), 914. https://doi.org/10.3390/cells11050914. PMid:35269536.

12 Kaasi, A., & Jardini, A. L. (2016). Bioreactors. In S. Hashmi. (Ed.), Reference module in materials science and materials engineering. Amsterdam: Elsevier. https://doi.org/10.1016/B978-0-12-803581-8.04140-0.

13 Williams, D. F. (2019). Challenges with the development of biomaterials for sustainable tissue engineering. Frontiers in Bioengineering and Biotechnology, 7, 127. https://doi.org/10.3389/fbioe.2019.00127. PMid:31214584.

14 Ameer, J. M., Pr, A. K., & Kasoju, N. (2019). Strategies to tune electrospun scaffold porosity for effective cell response in tissue engineering. Journal of Functional Biomaterials, 10(3), 30. https://doi.org/10.3390/jfb10030030. PMid:31324062.

15 Santos, A. R., Jr., & Zavaglia, C. A. C. (2016). Tissue engineering concepts. In S. Hashmi. (Ed.), Reference module in materials science and materials engineering. Amsterdam: Elsevier. https://doi.org/10.1016/B978-0-12-803581-8.04141-2

16 Karamanos, N. K., Theocharis, A. D., Piperigkou, Z., Manou, D., Passi, A., Skandalis, S. S., Vynios, D. H., Orian-Rousseau, V., Ricard-Blum, S., Schmelzer, C. E. H., Duca, L., Durbeej, M., Afratis, N. A., Troeberg, L., Franchi, M., Masola, V., & Onisto, M. (2021). A guide to the composition and functions of the extracellular matrix. The FEBS Journal, 288(24), 6850-6912. https://doi.org/10.1111/febs.15776. PMid:33605520.

17 Cai, S., Wu, C., Yang, W., Liang, W., Yu, H., & Liu, L. (2020). Recent advance in surface modification for regulating cell adhesion and behaviors. Nanotechnology Reviews, 9(1), 971-989. https://doi.org/10.1515/ntrev-2020-0076.

18 Sánchez-Bodón, J., Diaz-Galbarriatu, M., Pérez-Álvarez, L., Moreno-Benítez, I., & Vilas-Vilela, J. L. (2023). Strategies to enhance biomedical device performance and safety: a comprehensive review. Coatings, 13(12), 1981. https://doi.org/10.3390/coatings13121981.

19 Festas, A. J., Ramos, A., & Davim, J. P. (2020). Medical devices biomaterials: a review. Proceedings of the Institution of Mechanical Engineers. Proceedings Part L, Journal of Materials: Design and Applications, 234(1), 218-228. https://doi.org/10.1177/1464420719882458.

20 Crawford, L., Wyatt, M., Bryers, J., & Ratner, B. (2021). Biocompatibility evolves: phenomenology to toxicology to regeneration. Advanced Healthcare Materials, 10(11), e2002153. https://doi.org/10.1002/adhm.202002153. PMid:33829678.

21 Ghasemi-Mobarakeh, L., Kolahreez, D., Ramakrishna, S., & Williams, D. (2019). Key terminology in biomaterials and biocompatibility. Current Opinion in Biomedical Engineering, 10, 45-50. https://doi.org/10.1016/j.cobme.2019.02.004.

22 Williams, D. F. (2009). On the nature of biomaterials. Biomaterials, 30(30), 5897-5909. https://doi.org/10.1016/j.biomaterials.2009.07.027. PMid:19651435.

23 Chen, Q., & Thouas, G. A. (2015). Metallic implant biomaterials. Materials Science and Engineering R Reports, 87, 1-57. https://doi.org/10.1016/j.mser.2014.10.001.

24 Williams, D. F. (2017). Biocompatibility pathways: biomaterials-induced sterile inflammation, mechanotransduction, and principles of biocompatibility control. ACS Biomaterials Science & Engineering, 3(1), 2-35. https://doi.org/10.1021/acsbiomaterials.6b00607. PMid:33429689.

25 Williams, D. F. (2008). On the mechanisms of biocompatibility. Biomaterials, 29(20), 2941-2953. https://doi.org/10.1016/j.biomaterials.2008.04.023. PMid:18440630.

26 Chen, P.-R., Kang, P.-L., Su, W.-Y., Lin, F.-H., & Chen, M.-H. (2005). The evaluation of thermal properties and in vitro test of carbodiimide or glutaraldehyde cross-linked gelatin for PC 12 cells culture. Biomedical Engineering : Applications, Basis, and Communications, 17(2), 101-107. https://doi.org/10.4015/S1016237205000160.

27 Luo, J., Walker, M., Xiao, Y., Donnelly, H., Dalby, M. J., & Salmeron-Sanchez, M. (2021). The influence of nanotopography on cell behaviour through interactions with the extracellular matrix: a review. Bioactive Materials, 15, 145-159. https://doi.org/10.1016/j.bioactmat.2021.11.024. PMid:35386337.

28 Kanchanawong, P., & Calderwood, D. A. (2023). Organization, dynamics and mechanoregulation of integrin-mediated cell–ECM adhesions. Nature Reviews. Molecular Cell Biology, 24(2), 142-161. https://doi.org/10.1038/s41580-022-00531-5. PMid:36168065.

29 Zhang, F., & King, M. W. (2020). Biodegradable polymers as the pivotal player in the design of tissue engineering scaffolds. Advanced Healthcare Materials, 9(13), e1901358. https://doi.org/10.1002/adhm.201901358. PMid:32424996.

30 Sussman, E. M., Halpin, M. C., Muster, J., Moon, R. T., & Ratner, B. D. (2014). Porous implants modulate healing and induce shifts in local macrophage polarization in the foreign body reaction. Annals of Biomedical Engineering, 42(7), 1508-1516. https://doi.org/10.1007/s10439-013-0933-0. PMid:24248559.

31 Arzash, S., Shivers, J. L., & MacKintosh, F. C. (2021). Shear-induced phase transition and critical exponents in three-dimensional fiber networks. Physical Review. E, 104(2), L022402. https://doi.org/10.1103/PhysRevE.104.L022402. PMid:34525571.

32 Storm, C., Pastore, J. J., MacKintosh, F. C., Lubensky, T. C., & Janmey, P. A. (2005). Nonlinear elasticity in biological gels. Nature, 435(7039), 191-194. https://doi.org/10.1038/nature03521. PMid:15889088.

33 Fu, Q., Saiz, E., Rahaman, M. N., & Tomsia, A. P. (2011). Bioactive glass scaffolds for bone tissue engineering: state of the art and future perspectives. Materials Science and Engineering C, 31(7), 1245-1256. https://doi.org/10.1016/j.msec.2011.04.022. PMid:21912447.

34 Trappmann, B., Gautrot, J. E., Connelly, J. T., Strange, D. G. T., Li, Y., Oyen, M. L., Cohen Stuart, M. A., Boehm, H., Li, B., Vogel, V., Spatz, J. P., Watt, F. M., & Huck, W. T. S. (2012). Extracellular-matrix tethering regulates stem-cell fate. Nature Materials, 11(7), 642-649. https://doi.org/10.1038/nmat3339. PMid:22635042.

35 Tang, L., Thevenot, P., & Hu, W. (2008). Surface chemistry influences implant biocompatibility. Current Topics in Medicinal Chemistry, 8(4), 270-280. https://doi.org/10.2174/156802608783790901. PMid:18393890.

36 Patel, N. R., & Gohil, P. P. (2012). A review on biomaterials: scope, applications & human anatomy significance. International Journal of Emerging Technology and Advanced Engineering, 2(4), 91-101. Retrieved in 2025, August 13, from https://www.academia.edu/download/114306336/IJETAE_0412_17.pdf

37 Ratner, B. D., Hoffman, A. S., Schoen, F. J., & Lemons, J. E. (Eds.). (2004). Biomaterials science: an introduction to materials in medicine. San Diego: Academic Press. https://doi.org/10.1016/B978-0-08-087780-8.00148-0.

38 Jammalamadaka, U., & Tappa, K. (2018). Recent advances in biomaterials for 3D printing and tissue engineering. Journal of Functional Biomaterials, 9(1), 22. https://doi.org/10.3390/jfb9010022. PMid:29494503.

39 Spicer, C. D. (2020). Hydrogel scaffolds for tissue engineering: the importance of polymer choice. Polymer Chemistry, 11(2), 184-219. https://doi.org/10.1039/C9PY01021A.

40 Singh, R., Bathaei, M. J., Istif, E., & Beker, L. (2020). A review of bioresorbable implantable medical devices: materials, fabrication, and implementation. Advanced Healthcare Materials, 9(18), e2000790. https://doi.org/10.1002/adhm.202000790. PMid:32790033.

41 Chen, F.-M., & Liu, X. (2016). Advancing biomaterials of human origin for tissue engineering. Progress in Polymer Science, 53, 86-168. https://doi.org/10.1016/j.progpolymsci.2015.02.004. PMid:27022202.

42 Jafari, M., Paknejad, Z., Rad, M. R., Motamedian, S. R., Eghbal, M. J., Nadjmi, N., & Khojasteh, A. (2017). Polymeric scaffolds in tissue engineering: a literature review. Journal of Biomedical Materials Research. Part B, Applied Biomaterials, 105(2), 431-459. https://doi.org/10.1002/jbm.b.33547. PMid:26496456.

43 Naomi, R., Bahari, H., Ridzuan, P. M., & Othman, F. (2021). Natural-based biomaterial for skin wound healing (Gelatin vs. collagen): expert review. Polymers, 13(14), 2319. https://doi.org/10.3390/polym13142319. PMid:34301076.

44 Alipal, J., Mohd Pu’ad, N. A. S., Lee, T. C., Nayan, N. H. M., Sahari, N., Basri, H., Idris, M. I., & Abdullah, H. Z. (2021). A review of gelatin: Properties, sources, process, applications, and commercialisation. Materials Today: Proceedings, 42(Part 1), 240-250. https://doi.org/10.1016/j.matpr.2020.12.922.

45 Bello, A. B., Kim, D., Kim, D., Park, H., & Lee, S.-H. (2020). Engineering and functionalization of gelatin biomaterials: from cell culture to medical applications. Tissue Engineering. Part B, Reviews, 26(2), 164-180. https://doi.org/10.1089/ten.teb.2019.0256. PMid:31910095.

46 Giorno, L. P., Malmonge, S. M., & Santos, A. R., Jr. (2025). Collagen as a biomaterial for skin wound healing: from structural characteristics to the production of devices for tissue engineering. The International Journal of Artificial Organs, 48(3), 135-145. https://doi.org/10.1177/03913988251316437. PMid:39894968.

47 Mogoşanu, G. D., & Grumezescu, A. M. (2014). Natural and synthetic polymers for wounds and burns dressing. International Journal of Pharmaceutics, 463(2), 127-136. https://doi.org/10.1016/j.ijpharm.2013.12.015. PMid:24368109.

48 Sajkiewicz, P., & Kołbuk, D. (2014). Electrospinning of gelatin for tissue engineering–molecular conformation as one of the overlooked problems. Journal of Biomaterials Science. Polymer Edition, 25(18), 2009-2022. https://doi.org/10.1080/09205063.2014.975392. PMid:25357002.

49 Bella, J. (2016). Collagen structure: new tricks from a very old dog. The Biochemical Journal, 473(8), 1001-1025. https://doi.org/10.1042/BJ20151169. PMid:27060106.

50 Sionkowska, A., Skrzyński, S., Śmiechowski, K., & Kołodziejczak, A. (2017). The review of versatile application of collagen. Polymers for Advanced Technologies, 28(1), 4-9. https://doi.org/10.1002/pat.3842.

51 Campiglio, C. E., Negrini, N. C., Farè, S., & Draghi, L. (2019). Cross-linking strategies for electrospun gelatin scaffolds. Materials, 12(15), 2476. https://doi.org/10.3390/ma12152476. PMid:31382665.

52 Gorgieva, S., & Kokol, V. (2011). Collagen-vs. gelatine-based biomaterials and their biocompatibility: review and perspectives. In R. Pignatello (Ed.), Biomaterials applications for nanomedicine (pp. 17-52). London: IntechOpen. https://doi.org/10.5772/24118

53 Lakshminarayanan, R., Sridhar, R., Loh, X. J., Nandhakumar, M., Barathi, V. A., Kalaipriya, M., Kwan, J. L., Liu, S. P., Beuerman, R. W., & Ramakrishna, S. (2014). Interaction of gelatin with polyenes modulates antifungal activity and biocompatibility of electrospun fiber mats. International Journal of Nanomedicine, 9(1), 2439-2458. https://doi.org/10.2147/IJN.S58487. PMid:24920895.

54 Echave, M. C., Saenz del Burgo, L., Pedraz, J. L., & Orive, G. (2017). Gelatin as biomaterial for tissue engineering. Current Pharmaceutical Design, 23(24), 3567-3584. https://doi.org/10.2174/0929867324666170511123101. PMid:28494717.

55 Jeong, J. E., Park, S. Y., Shin, J. Y., Seok, J. M., Byun, J. H., Oh, S. H., Kim, W. D., Lee, J. H., Park, W. H., & Park, S. A. (2020). 3D printing of bone‐mimetic scaffold composed of gelatin/β‐tri‐calcium phosphate for bone tissue engineering. Macromolecular Bioscience, 20(12), e2000256. https://doi.org/10.1002/mabi.202000256. PMid:33164317.

56 Quint, J. P., Mostafavi, A., Endo, Y., Panayi, A., Russell, C. S., Nourmahnad, A., Wiseman, C., Abbasi, L., Samandari, M., Sheikhi, A., Nuutila, K., Sinha, I., & Tamayol, A. (2021). In vivo printing of nanoenabled scaffolds for the treatment of skeletal muscle injuries. Advanced Healthcare Materials, 10(10), e2002152. https://doi.org/10.1002/adhm.202002152. PMid:33644996.

57 Lee, S. S., Santschi, M., & Ferguson, S. J. (2022). Correction to “A biomimetic macroporous hybrid scaffold with sustained drug delivery for enhanced bone regeneration”. Biomacromolecules, 23(3), 1474. https://doi.org/10.1021/acs.biomac.2c00203. PMid:35195985.

58 Echave, M. C., Erezuma, I., Golafshan, N., Castilho, M., Kadumudi, F. B., Pimenta-Lopes, C., Ventura, F., Pujol, A., Jimenez, J. J., Camara, J. A., Hernáez-Moya, R., Iturriaga, L., Sáenz Del Burgo, L., Iloro, I., Azkargorta, M., Elortza, F., Lakshminarayanan, R., Al-Tel, T. H., García-García, P., Reyes, R., Delgado, A., Évora, C., Pedraz, J. L., Dolatshahi-Pirouz, A., & Orive, G. (2022). Bioinspired gelatin/bioceramic composites loaded with bone morphogenetic protein-2 (BMP-2) promote osteoporotic bone repair. Biomaterials Advances, 134, 112539. https://doi.org/10.1016/j.msec.2021.112539. PMid:35513949.

59 Lukin, I., Erezuma, I., Maeso, L., Zarate, J., Desimone, M. F., Al-Tel, T. H., Dolatshahi-Pirouz, A., & Orive, G. (2022). Progress in gelatin as biomaterial for tissue engineering. Pharmaceutics, 14(6), 1177. https://doi.org/10.3390/pharmaceutics14061177. PMid:35745750.

60 Siddiqui, N., Asawa, S., Birru, B., Baadhe, R., & Rao, S. (2018). PCL-based composite scaffold matrices for tissue engineering applications. Molecular Biotechnology, 60(7), 506-532. https://doi.org/10.1007/s12033-018-0084-5. PMid:29761314.

61 Woodruff, M. A., & Hutmacher, D. W. (2010). The return of a forgotten polymer: polycaprolactone in the 21st century. Progress in Polymer Science, 35(10), 1217-1256. https://doi.org/10.1016/j.progpolymsci.2010.04.002.

62 Kweon, H. Y., Yoo, M. K., Park, I. K., Kim, T. H., Lee, H. C., Lee, H.-S., Oh, J.-S., Akaike, T., & Cho, C.-S. (2003). A novel degradable polycaprolactone networks for tissue engineering. Biomaterials, 24(5), 801-808. https://doi.org/10.1016/S0142-9612(02)00370-8. PMid:12485798.

63 Krasowska, K., Heimowska, A., & Morawska, M. (2016). Environmental degradability of polycaprolactone under natural conditions. E3S Web of Conferences, 10, 00048. https://doi.org/10.1051/e3sconf/20161000048.

64 O’Brien, F. J. (2011). Biomaterials & scaffolds for tissue engineering. Materials Today, 14(3), 88-95. https://doi.org/10.1016/S1369-7021(11)70058-X.

65 Simbara, M. M. O., Santos, A. R., Jr., Andrade, A. J. P., & Malmonge, S. M. (2019). Comparative study of aligned and nonaligned poly (ε‐caprolactone) fibrous scaffolds prepared by solution blow spinning. Journal of Biomedical Materials Research. Part B, Applied Biomaterials, 107(5), 1462-1470. https://doi.org/10.1002/jbm.b.34238. PMid:30265779.

66 Giorno, L. P., Rodrigues, L. R., & Santos, A. R., Jr. (2022). Characterization and in vitro analysis of a poly (ε-caprolactone)-gelatin matrix produced by rotary jet spinning and applied as a skin dressing. Polymer Bulletin, 79(10), 9131-9158. https://doi.org/10.1007/s00289-022-04228-9.

67 Mizuno, Y., & Taguchi, T. (2020). Self-assembled dodecyl group-modified gelatin microparticle-based hydrogels with angiogenic properties. NPG Asia Materials, 12(1), 48. https://doi.org/10.1038/s41427-020-0229-4.

68 Askari, E., Naghib, S. M., Zahedi, A., Seyfoori, A., Zare, Y., & Rhee, K. Y. (2021). Local delivery of chemotherapeutic agent in tissue engineering based on gelatin/graphene hydrogel. Journal of Materials Research and Technology, 12, 412-422. https://doi.org/10.1016/j.jmrt.2021.02.084.

69 Daikuara, L. Y., Yue, Z., Skropeta, D., & Wallace, G. G. (2021). In vitro characterisation of 3D printed platelet lysate-based bioink for potential application in skin tissue engineering. Acta Biomaterialia, 123, 286-297. https://doi.org/10.1016/j.actbio.2021.01.021. PMid:33476829.

70 Machado-Paula, M. M., Corat, M. A. F., Lancellotti, M., Mi, G., Marciano, F. R., Vega, M. L., Hidalgo, A. A., Webster, T. J., & Lobo, A. O. (2020). A comparison between electrospinning and rotary-jet spinning to produce PCL fibers with low bacteria colonization. Materials Science and Engineering C, 111, 110706. https://doi.org/10.1016/j.msec.2020.110706. PMid:32279777.

71 Muniz, N. O., Vechietti, F. A., Anesi, G. R., Guinea, G. V., & Santos, L. A. L. (2020). Blend-based fibers produced via centrifugal spinning and electrospinning processes: physical and rheological properties. Journal of Materials Research, 35(21), 2905-2916. https://doi.org/10.1557/jmr.2020.189.

72 Hong, J., Yeo, M., Yang, G. H., & Kim, G. (2019). Cell-electrospinning and its application for tissue engineering. International Journal of Molecular Sciences, 20(24), 6208. https://doi.org/10.3390/ijms20246208. PMid:31835356.

73 Prakashan, D., Singh, A., Deshpande, A. D., Chandra, V., Sharma, G. T., & Gandhi, S. (2024). Bone marrow derived mesenchymal stem cells enriched PCL-gelatin nanofiber scaffold for improved wound healing. International Journal of Biological Macromolecules, 274(Pt 2), 133447. https://doi.org/10.1016/j.ijbiomac.2024.133447. PMid:38944073.

74 Singh, A., Prakashan, D., Deshpande, A. D., Likhitha, B. N., Shukla, S., Emmanuel, R. S., Thirupathi, Y., Saikumar, G., Pal, A., Chandra, V., Gandhi, S., & Sharma, G. T. (2025). Mesenchymal stem cells laden polycaprolactone gelatin hybrid nanoscaffold for repair of radius segmental defect. Journal of Drug Delivery Science and Technology, 111, 107187. https://doi.org/10.1016/j.jddst.2025.107187.

75 Bahú, J. O., Andrade, L. R. M., Crivellin, S., Khouri, N. G., Sousa, S. O., Fernandes, L. M. I., Souza, S. D. A., Cárdenas Concha, L. S. C., Schiavon, M. I. R. B., Benites, C. I., Severino, P., Souto, E. B., & Concha, V. O. C. (2022). Rotary jet spinning (RJS): a key process to produce biopolymeric wound dressings. Pharmaceutics, 14(11), 2500. https://doi.org/10.3390/pharmaceutics14112500. PMid:36432691.

76 Badrossamay, M. R., McIlwee, H. A., Goss, J. A., & Parker, K. K. (2010). Nanofiber assembly by rotary jet-spinning. Nano Letters, 10(6), 2257-2261. https://doi.org/10.1021/nl101355x. PMid:20491499.

77 Medeiros, E. S., Glenn, G. M., Klamczynski, A. P., Orts, W. J., & Mattoso, L. H. C. (2009). Solution blow spinning: a new method to produce micro‐and nanofibers from polymer solutions. Journal of Applied Polymer Science, 113(4), 2322-2330. https://doi.org/10.1002/app.30275.

78 Khan, K. R., & Hassan, M. N. (2021). Solution Blow Spinning (SBS): a promising spinning system for submicron/nanofibre production. Textile & Leather Review, 4(3), 181-200. https://doi.org/10.31881/TLR.2021.04.

79 Hell, A. F., Simbara, M. M. O., Rodrigues, P., Kakazu, D. A., & Malmonge, S. M. (2018). Production of fibrous polymer scaffolds for tissue engineering using an automated solution blow spinning system. Research on Biomedical Engineering, 34(3), 273-278. https://doi.org/10.1590/2446-4740.180039.

80 Gao, Y., Zhang, J., Su, Y., Wang, H., Wang, X.-X., Huang, L.-P., Yu, M., Ramakrishna, S., & Long, Y.-Z. (2021). Recent progress and challenges in solution blow spinning. Materials Horizons, 8(2), 426-446. https://doi.org/10.1039/D0MH01096K. PMid:34821263.

81 Demina, T. S., Bolbasov, E. N., Peshkova, M. A., Efremov, Y. M., Bikmulina, P. Y., Birdibekova, A. V., Popyrina, T. N., Kosheleva, N. V., Tverdokhlebov, S. I., Timashev, P. S., & Akopova, T. A. (2022). Electrospinning vs. electro-assisted solution blow spinning for fabrication of fibrous scaffolds for tissue engineering. Polymers, 14(23), 5254. https://doi.org/10.3390/polym14235254. PMid:36501648.

82 Czarnecka, K., Wojasiński, M., Ciach, T., & Sajkiewicz, P. (2021). Solution blow spinning of polycaprolactone: rheological determination of spinnability and the effect of processing conditions on fiber diameter and alignment. Materials, 14(6), 1463. https://doi.org/10.3390/ma14061463. PMid:33802725.

83 Lu, L., Arbit, H. M., Herrick, J. L., Segovis, S. G., Maran, A., & Yaszemski, M. J. (2015). Tissue engineered constructs: perspectives on clinical translation. Annals of Biomedical Engineering, 43(3), 796-804. https://doi.org/10.1007/s10439-015-1280-0. PMid:25711151.

84 Capella-Monsonís, H., Crum, R. J., Hussey, G. S., & Badylak, S. F. (2024). Advances, challenges, and future directions in the clinical translation of ECM biomaterials for regenerative medicine applications. Advanced Drug Delivery Reviews, 211, 115347. https://doi.org/10.1016/j.addr.2024.115347. PMid:38844005.

85 Xu, C., & Ivanovski, S. (2025). Clinical translation of personalized bioengineered implant scaffolds. Nature Reviews Bioengineering, 3(5), 390-407. https://doi.org/10.1038/s44222-024-00269-z.

86 Evans, C. H. (2011). Barriers to the clinical translation of orthopedic tissue engineering. Tissue Engineering. Part B, Reviews, 17(6), 437-441. https://doi.org/10.1089/ten.teb.2011.0228. PMid:21682607.
 

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