Polímeros: Ciência e Tecnologia
https://revistapolimeros.org.br/article/doi/10.1590/0104-1428.20230061
Polímeros: Ciência e Tecnologia
Original Article

New bioresorbable filaments for scaffolds intending local sodium alendronate release

Olivia Deretti; Guilherme Tait; Lucas Werner; Luana Engelmann; Denise Abatti Kasper Silva; Ana Paula Testa Pezzin

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Abstract

Scaffolds with osteoconductivity, biocompatibility and good mechanical properties are promising for local drug release of sodium alendronate (ALN), a first-choice drug for treatment of bone tissue diseases, with low bioavailability. The viability to manufacture poly (L-lactic acid) (PLLA)/poly (methyl methacrylate) (PMMA) filaments containing ALN in different proportions, through extrusion, followed by scaffolds using 3D printing by fusion deposition modelling (FDM) and to investigate the influence of processes in mixtures drove this study. Differential scanning calorimetry (DSC), spectroscopy in the infrared region with Fourier transform (FTIR/ATR), and X-ray diffractometry (XRD) analysis indicated that PMMA decelerates crystallinity and confers malleability to PLLA/ALN mixture, besides its good processability and miscibility with PLLA and no relevant changes in physicochemical properties of components. Field emission scanning electron microscopy (SEM/FEG) showed good interfacial compatibility between PLLA/PMMA and homogeneously dispersed drug crystals in matrix. PLLA-PMMA-ALN scaffolds were manufactured by accurate with interesting properties for bone tissue engineering.

 

Keywords

filaments characteristics, polyesters, second generation bisphosphonate

References

1 Tarafder, S., & Bose, S. (2014). Polycaprolactone-coated 3D printed tricalcium phosphate scaffolds for bone tissue engineering: in vitro alendronate release behavior and local delivery effect on in vivo osteogenesis. ACS Applied Materials & Interfaces, 6(13), 9955-9965. http://doi.org/10.1021/am501048n. PMid:24826838.

2 Posadowska, U., Parizek, M., Filova, E., Wlodarczyk-Biegun, M., Kamperman, M., Bacakova, L., & Pamula, E. (2015). Injectable nanoparticle-loaded hydrogel system for local delivery of sodium alendronate. International Journal of Pharmaceutics, 485(1-2), 31-40. http://doi.org/10.1016/j.ijpharm.2015.03.003. PMid:25747455.

3 Mir, M., Ahmed, N., & Rehman, A. (2017). Recent applications of PLGA based nanostructures in drug delivery. Colloids and Surfaces. B, Biointerfaces, 159, 217-231. http://doi.org/10.1016/j.colsurfb.2017.07.038. PMid:28797972.

4 Li, D., Guo, G., Deng, X., Fan, R., Guo, Q., Fan, M., Liang, J., Luo, F., & Qian, Z. (2013). PLA/PEG-PPG-PEG/Dexamethasone implant prepared by hot-melt extrusion for controlled release of immunosuppressive drug to implantable medical devices, part 2: in vivo evaluation. Drug Delivery, 20(3-4), 134-142. http://doi.org/10.3109/10717544.2013.801049. PMid:23745720.

5 Wang, Y., Sun, L., Mei, Z., Zhang, F., He, M., Fletcher, C., Wang, F., Yang, J., Bi, D., Jiang, Y., & Liu, P. (2020). 3D printed biodegradable implants as an individualized drug delivery system for local chemotherapy of osteosarcoma. Materials & Design, 186, 108336. http://doi.org/10.1016/j.matdes.2019.108336.

6 Awad, A., Fina, F., Goyanes, A., Gaisford, S., & Basit, A. W. (2021). Advances in powder bed fusion 3D printing in drug delivery and healthcare. Advanced Drug Delivery Reviews, 174, 406-424. http://doi.org/10.1016/j.addr.2021.04.025. PMid:33951489.

7 Jamróz, W., Kurek, M., Łyszczarz, E., Brniak, W., & Jachowicz, R. (2017). Printing techniques: recent developments in pharmaceutical technology. Acta Poloniae Pharmaceutica - Drug Research, 74(3), 753-763. PMid:29513944.

8 Goole, J., & Amighi, K. (2016). 3D printing in pharmaceutics: a new tool for designing customized drug delivery systems. International Journal of Pharmaceutics, 499(1-2), 376-394. http://doi.org/10.1016/j.ijpharm.2015.12.071. PMid:26757150.

9 Goyanes, A., Allahham, N., Trenfield, S. J., Stoyanov, E., Gaisford, S., & Basit, A. W. (2019). Direct powder extrusion 3D printing: fabrication of drug products using a novel single-step process. International Journal of Pharmaceutics, 567, 118471. http://doi.org/10.1016/j.ijpharm.2019.118471. PMid:31252147.

10 Danda, L. J. A., Batista, L. M., Melo, V. C. S., Soares Sobrinho, J. L., & Soares, M. F. L. R. (2019). Combining amorphous solid dispersions for improved kinetic solubility of posaconazole simultaneously released from soluble PVP/VA64 and an in-soluble ammonio methacrylate copolymer. European Journal of Pharmaceutical Sciences, 133, 79-85. http://doi.org/10.1016/j.ejps.2019.03.012. PMid:30890364.

11 Sayanjali, S., Sanguansri, L., Ying, D., Buckow, R., Gras, S., & Augustin, M. A. (2019). Extrusion of a curcuminoid-enriched oat fiber-corn-based snack product. Journal of Food Science, 84(2), 284-291. http://doi.org/10.1111/1750-3841.14432. PMid:30648743.

12 Domínguez-Robles, J., Martin, N. K., Fong, M. L., Stewart, S. A., Irwin, N. J., Rial-Hermida, M. I., Donnelly, R. F., & Larrañeta, E. (2019). Antioxidant PLA composites containing lignin for 3d printing applications: a potential material for healthcare applications. Pharmaceutics, 11(4), 165. http://doi.org/10.3390/pharmaceutics11040165. PMid:30987304.

13 Boetker, J., Water, J. J., Aho, J., Arnfast, L., Bohr, A., & Rantanen, J. (2016). Modifying release characteristics from 3D printed drug-eluting products. European Journal of Pharmaceutical Sciences, 90, 47-52. http://doi.org/10.1016/j.ejps.2016.03.013. PMid:26987609.

14 Tyler, B., Gullotti, D., Mangraviti, A., Utsuki, T., & Brem, H. (2016). Polylactic acid (PLA) controlled delivery carriers for biomedical applications. Advanced Drug Delivery Reviews, 107, 163-175. http://doi.org/10.1016/j.addr.2016.06.018. PMid:27426411.

15 Anakabe, J., Orue, A., Huici, A. M. Z., Eceiza, A., & Arbelaiz, A. (2018). Properties of PLA/PMMA blends with high polylactide content prepared by reactive mixing in presence of poly (styrene-co-glycidyl methacrylate) copolymer. Journal of Applied Polymer Science, 135(43), 46825. http://doi.org/10.1002/app.46825.

16 Camargo, E., Serafim, B. M., Cruz, A. F., Soares, P., Oliveira, C. C., Saul, C. K., & Marino, C. E. B. (2021). Bioactive response of PMMA coating obtained by electrospinning on ISO5832-9 and Ti6Al4V biomaterials. Surface and Coatings Technology, 412, 127033. http://doi.org/10.1016/j.surfcoat.2021.127033.

17 Siqueira, A. (2018). Obtenção de scaffolds poliméricos baseados em poli (ácido láctico), hidroxiapatita e óxido de grafeno utilizado o método de manufatura aditiva por “fused deposition modelling” (Master’s dissertation). Universidade Presbitariana Mackenzie, São Paulo.

18 Asnani, M., Vyas, K., Bhattacharya, A., Devarakonda, S., Chakraborty, S., & Mukherjee, A. K. (2009). Ab initio structure determination of anhydrous sodium alendronate from laboratory powder X-ray diffraction data. Journal of Pharmaceutical Sciences, 98(6), 2113-2121. http://doi.org/10.1002/jps.21561. PMid:18781644.

19 Silva-Buzanello, R. A., Souza, M. F., Oliveira, D. A., Bona, E., Leimann, F. V., Cardozo, L., Fo., Araújo, P. H. H., Ferreira, S. R. S., & Gonçalves, O. H. (2016). Preparation of curcumin-loaded nanoparticles and determination of the antioxidant potential of curcumin after encapsulation. Polímeros, 26(3), 207-214. http://doi.org/10.1590/0104-1428.2246.

20 Garlotta, D. (2001). A literature review of poly (lactic acid). Journal of Polymers and the Environment, 9(2), 63-84. http://doi.org/10.1023/A:1020200822435.

21 Deretti, O. (2022). Novos filamentos biorreabsorvíveis para scaffolds visando a administração local de alendronato de sódio (Master’s dissertation). Universidade da Região de Joinville, Joinville.

22 Cifuentes, S. C., Lieblich, M., Lopez, F. A., Benavente, F., & Gonzáles-Carrasco, J. L. (2017). Effect of Mg content on the thermal stability and mechanical behaviour of PLLA/Mg composites processed by hot extrusion. Materials Science and Engineering C, 72, 18-25. http://doi.org/10.1016/j.msec.2016.11.037. PMid:28024575.

23 Water, J. J., Bohr, A., Boetker, J., Aho, J., Sandler, N., Nielsen, H. M., & Rantanen, J. (2015). Three-dimensional printing of drug-eluting implants: preparation of an antimicrobial polylactide feedstock material. Journal of Pharmaceutical Sciences, 104(3), 1099-1107. http://doi.org/10.1002/jps.24305. PMid:25640314.

24 Yuniarto, K., Purwanto, Y. A., Purwanto, S., Welt, B. A., Purwadaria, H. K., & Sunarti, T. C. (2016). Infrared and Raman studies on polylactide acid and polyethylene glycol-400 blend. AIP Conference Proceedings, 1725(1), 020101. http://doi.org/10.1063/1.4945555.

25 Bitencourt, S. S., Batista, K. C., Zattera, A. J., Silva, D. A. K., & Pezzin, A. P. T. (2017). Development of poly (L-lactic acid PLLA) biocomposites with waste wood. Revista Matéria, 22(4), e11899.

26 Ferrández-Montero, A., Lieblich, M., Benavente, R., Gonzáles-Carrasco, J. L., & Ferrari, B. (2020). Study of the matrix-filler interface in PLA/Mg composites manufactured by material extrusion using a colloidal feedstock. Additive Manufacturing, 33, 101142. http://doi.org/10.1016/j.addma.2020.101142.

27 Oz, U. C., Küçüktürkmen, B., Devrim, B., Saka, O. M., & Bozkir, A. (2019). Development and optimization of alendronate sodium loaded PLGA nanoparticles by central composite design. Macromolecular Research, 27(9), 857-866. http://doi.org/10.1007/s13233-019-7119-z.

28 Wang, S., Capoen, L., D’Hooge, D. R., & Cardon, L. (2018). Can the melt flow index be used to predict the success of fused deposition modelling of commercial poly (lactic acid) filaments into 3D printed materials? Plastics, Rubber and Composites, 47(1), 9-16. http://doi.org/10.1080/14658011.2017.1397308.

29 Silveira, E. (2015). Estudo da tenacificação do PLA pela adição de elastômero termoplástico EMA-GMA (Master’s dissertation). Escola Politécnica, Universidade de São Paulo, São Paulo.

30 Ju, J., Peng, X., Huang, K., Li, L., Liu, X., Chitrakar, C., Chang, L., Gu, Z., & Kuang, T. (2019). High-performance porous PLLA-based scaffolds for bone tissue engineering: Preparation, characterization, and in vitro and in vivo evaluation. Polymer, 180, 121707. http://doi.org/10.1016/j.polymer.2019.121707.

31 Agüero, Á., Garcia-Sanoguera, D., Lascano, D., Rojas-Lema, S., Ivorra-Martinez, J., Fenollar, O., & Torres-Giner, S. (2020). Evaluation of different compatibilization strategies to improve the performance of injection-molded green composite pieces made of polylactide reinforced with short flaxseed fibers. Polymers, 12(4), 821. http://doi.org/10.3390/polym12040821. PMid:32260439.

32 Huang, Y., Liu, Y., & Zhao, C. (1998). Morphology and properties of PETE/PA-6/E-44 blends. Journal of Applied Polymer Science, 69(8), 1505-1515. http://doi.org/10.1002/(SICI)1097-4628(19980822)69:8<1505::AID-APP4>3.0.CO;2-G.

33 Delabarde, C., Plummer, C. J. G., Bourban, P.-E., & Manson, J.-A. E. (2010). Solidification behaviour of PLLA/nHA nanocomposites. Composites Science and Technology, 70(13), 1813-1819. http://doi.org/10.1016/j.compscitech.2010.04.024.

34 Haser, A., Huang, S., Listro, T., White, D., & Zhang, F. (2017). An approach for chemical stability during melt extrusion of a drug substance with a high melting point. International Journal of Pharmaceutics, 524(1-2), 55-64. http://doi.org/10.1016/j.ijpharm.2017.03.070. PMid:28359810.

35 Srivastava, A., Ahuja, R., Bhati, P., Singh, S., Chauhan, P., Vashisth, P., Kumar, A., & Bhatnagar, N. (2020). Fabrication and characterization of PLLA/Mg composite tube as the potential bioresorbable/biodegradable stent (BRS). Materialia, 10, 100661. http://doi.org/10.1016/j.mtla.2020.100661.

36 Wu, W., Zheng, Q., Guo, X., & Huang, W. (2009). The controlled-releasing drug implant based on the three-dimensional printing technology: fabrication and properties of. Journal Wuhan University of Technology-Materials Science Edition, 24(6), 977-981. http://doi.org/10.1007/s11595-009-6977-1.

37 Rosiak, P., Latanska, I., Paul, P., Sujka, W., & Kolesinska, B. (2021). Modification of alginates to modulate their physico-chemical properties and obtain biomaterials with different functional properties. Molecules, 26(23), 7264. http://doi.org/10.3390/molecules26237264. PMid:34885846.

38 Tidau, M., Kwade, A., & Finke, J. H. (2019). Influence of high, disperse API load on properties along the fused-layer modeling process chain of solid dosage forms. Pharmaceutics, 11(4), 194. http://doi.org/10.3390/pharmaceutics11040194. PMid:31013578.

39 Drummer, D., Cifuentes-Cuélar, S., & Rietzel, D. (2012). Suitability of PLA/TCP for fused deposition modeling. Rapid Prototyping Journal, 18(6), 500-507. http://doi.org/10.1108/13552541211272045.
 

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