Polímeros: Ciência e Tecnologia
https://revistapolimeros.org.br/article/doi/10.1590/0104-1428.1831
Polímeros: Ciência e Tecnologia
Scientific & Technical Article

Binary mixture micellar systems of F127 and P123 for griseofulvin solubilisation

Dutra, Lillian Maria Uchôa; Ribeiro, Maria Elenir Nobre Pinho; Cavalcante, Igor Marques; Brito, Débora Hellen Almeida de; Semião, Luana de Moraes; Silva, Raquel Freitas da; Fechine, Pierre Basílio Almeida; Yeates, Stephen George; Ricardo, Nágila Maria Pontes Silva

Downloads: 0
Views: 332

Abstract

Pluronics® molecules self-assemble in aqueous solution providing a core/shell architecture that improves the solubility of hydrophobic drugs. Binary mixtures of Pluronics® have been studied as drug nanocarriers in order to combine their advantages, like high colloidal stability, small particle size and good solubilisation capacity (Scp). In this work we studied Pluronics® binary mixture, P123 and F127, as nanocarriers of the hydrophobic drug griseofulvin. P123 (E21P67E21) shows a relative good Scp, whereas F127 (E98P67E98) shows a good colloidal stability. According to data, these binary mixtures form stables nano-sized comicelles in aqueous solution. The Scp of the P123/F127 systems at 25 and 37 °C was monitored by UV/Visible spectroscopy, showing good results at both temperatures, as would be expected, since P123/F127 have similar length hydrophobic block. Hydrophobic-dependence and temperature-responsive of the systems were evaluated by CMC, particle size and colloidal stability. Hence, stables P123/F127 comicelles may have potencial as hydrophobic drug delivery

Keywords

binary mixtures, griseofulvin, Pluronics.

References

1. Crothers, M., Zhou, Z., Ricardo, N. M. P. S., Yang, Z., Taboada, P., Chaibundit, C., Attwood, D., & Booth, C. (2005). Solubilisation in aqueous micellar solutions of block copoly(oxyalkylene)s. International Journal of Pharmaceutics, 293(1-2), 91-100. http://dx.doi.org/10.1016/j.ijpharm.2004.12.005. PMid:15778048.

2. Mora-Huertas, C. E., Fessi, H., & Elaissari, A. (2010). Polymer-based nanocapsules for drug delivery. International Journal of Pharmaceutics, 385(1-2), 113-142. http://dx.doi.org/10.1016/j.ijpharm.2009.10.018. PMid:19825408.

3. Xiong, X.-B., Falamarzian, A., Garg, S. M., & Lavasanifar, A. (2011). Engineering of amphiphilic block copolymers for polymeric micellar drug and gene delivery. Journal of Controlled Release, 155(2), 248-261. http://dx.doi.org/10.1016/j.jconrel.2011.04.028. PMid:21621570.

4. Elluru, M., Ma, H., Hadjiargyrou, M., Hsiao, B. S., & Chu, B. (2013). Synthesis and characterization of biocompatible hydrogel using Pluronics-based block copolymers. Polymer, 54(8), 2088-2095. http://dx.doi.org/10.1016/j.polymer.2013.02.017.

5. Jindal, N., & Mehta, S. K. (2015). Nevirapine loaded Poloxamer 407/Pluronic P123 mixed micelles: optimization of formulation and in vitro evaluation. Colloids and Surfaces B: Biointerfaces, 129, 100-106. http://dx.doi.org/10.1016/j.colsurfb.2015.03.030.

6. Kadam, Y., Yerramilli, U., Bahadur, A., & Bahadur, P. (2011). Micelles from PEO-PPO-PEO block copolymers as nanocontainers for solubilization of a poorly water soluble drug hydrochlorothiazide. Colloids and Surfaces B: Biointerfaces, 83(1), 49-57. http://dx.doi.org/10.1016/j.colsurfb.2010.10.041. PMid:21123038.

7. Zhang, W., Shi, Y., Chen, Y., Ye, J., Sha, X., & Fang, X. (2011). Multifunctional Pluronic P123/F127 mixed polymeric micelles loaded with paclitaxel for the treatment of multidrug resistant tumors. Biomaterials, 32(11), 2894-2906. http://dx.doi.org/10.1016/j.biomaterials.2010.12.039. PMid:21256584.

8. Lee, E. S., Oh, Y. T., Youn, Y. S., Nam, M., Park, B., Yun, J., Kim, J. H., Song, H.-T., & Oh, K. T. (2011). Binary mixing of micelles using Pluronics for a nano-sized drug delivery system. Colloids and Surfaces B: Biointerfaces, 82(1), 190-195. http://dx.doi.org/10.1016/j.colsurfb.2010.08.033. PMid:20850281.

9. Zhang, M., Djabourov, M., Bourgaux, C., & Bouchemal, K. (2013). Nanostructured fluids from pluronic® mixtures. International Journal of Pharmaceutics, 454(2), 599-610. http://dx.doi.org/10.1016/j.ijpharm.2013.01.043. PMid:23370436.

10. Alexandridis, P., Holzwarth, J. F., & Hatton, T. A. (1994). Micellization of Poly(ethylene oxide)-Poly(propylene oxide)-Poly(ethylene oxide) triblock copolymers in aqueous solutions: thermodynamics of copolymer association. Macromolecules, 27(9), 2414-2425. http://dx.doi.org/10.1021/ma00087a009.

11. Chaibundit, C., Ricardo, N. M. P. S., Costa, F. D. M. L. L., Yeates, S. G., & Booth, C. (2007). Micellization and gelation of mixed copolymers P123 and F127 in aqueous solution. Langmuir, 23(18), 9229-9236. http://dx.doi.org/10.1021/la701157j. PMid:17676776.

12. Wei, Z., Hao, J., Yuan, S., Li, Y., Juan, W., Sha, X., & Fang, X. (2009). Paclitaxel-loaded Pluronic P123/F127 mixed polymeric micelles: formulation, optimization and in vitro characterization. International Journal of Pharmaceutics, 376(1-2), 176-185. http://dx.doi.org/10.1016/j.ijpharm.2009.04.030. PMid:19409463.

13. Oh, K. T., Bronich, T. K., & Kabanov, A. V. (2004). Micellar formulations for drug delivery based on mixtures of hydrophobic and hydrophilic Pluronic® block copolymers. Journal of Controlled Release, 94(2-3), 411-422. http://dx.doi.org/10.1016/j.jconrel.2003.10.018. PMid:14744491.

14. Rekatas, C. J., Mai, S.-M., Crothers, M., Quinn, M., Collett, J. H., Attwood, D., Heatley, F., Martini, L., & Booth, C. (2001). The effect of hydrophobe chemical structure and chain length on the solubilization of griseofulvin in aqueous micellar solutions of block copoly(oxyalkylene)s. Physical Chemistry Chemical Physics, 3(21), 4769-4773. http://dx.doi.org/10.1039/b107073h.

15. Aliabadi, H. M., & Lavasanifar, A. (2006). Polymeric micelles for drug delivery. Expert Opinion on Drug Delivery, 3(1), 139-162. http://dx.doi.org/10.1517/17425247.3.1.139. PMid:16370946.

16. Ribeiro, M. E. N. P., Vieira, Í. G. P., Cavalcante, I. M., Ricardo, N. M. P. S., Attwood, D., Yeates, S. G., & Booth, C. (2009). Solubilisation of griseofulvin, quercetin and rutin in micellar formulations of triblock copolymers E62P39E62 and E137S18E137. International Journal of Pharmaceutics, 378(1-2), 211-214. http://dx.doi.org/10.1016/j.ijpharm.2009.05.047. PMid:19501147.

17. Zhong, N., Chen, H., Zhao, Q., Wang, H., Yu, X., Eaves, A. M., Sheng, W., Miao, J., Cui, F., & Wang, J. (2010). Effects of griseofulvin on apoptosis through caspase-3- and caspase-9-dependent pathways in K562 leukemia cells: An in vitro study. Current Therapeutic Research, Clinical and Experimental, 71(6), 384-397. http://dx.doi.org/10.1016/S0011-393X(10)80004-9. PMid:24688157.

18. Attwood, D., Booth, C., Yeates, S. G., Chaibundit, C., & Ricardo, N. M. P. S. (2007). Block copolymers for drug solubilisation: Relative hydrophobicities of polyether and polyester micelle-core-forming blocks. International Journal of Pharmaceutics, 345(1-2), 35-41. http://dx.doi.org/10.1016/j.ijpharm.2007.07.039. PMid:17869036.

19. Kulthe, S. S., Inamdar, N. N., Choudhari, Y. M., Shirolikar, S. M., Borde, L. C., & Mourya, V. K. (2011). Mixed micelle formation with hydrophobic and hydrophilic Pluronic block copolymers: Implications for controlled and targeted drug delivery. Colloids and Surfaces B: Biointerfaces, 88(2), 691-696. http://dx.doi.org/10.1016/j.colsurfb.2011.08.002. PMid:21862296.

20. Tadros, T. F. (2005). Applied Surfactants: principles and applications. Weinheim: WILEY-VCH.

21. Kadam, Y., Yerramilli, U., & Bahadur, A. (2009). Solubilization of poorly water-soluble drug carbamezapine in Pluronic® micelles: effect of molecular characteristics, temperature and added salt on the solubilizing capacity. Colloids and Surfaces B: Biointerfaces, 72(1), 141-147. http://dx.doi.org/10.1016/j.colsurfb.2009.03.027. PMid:19403275.

22. Attwood, D., & Booth, C. (2007). Solubilization of a poorly soluble aromatic drug by micellar solutions of amphiphilic block copoly(oxyalkylene)s. In T. F. Tadros (Ed.), Colloid stability and application in pharmacy (pp. 61-78). Weinheim: Wiley-VCH.

23. Attia, A. B. E., Ong, Z. Y., Hedrick, J. L., Lee, P. P., Ee, P. L. R., Hammond, P. T., & Yang, Y.-Y. (2011). Mixed micelles self-assembled from block copolymers for drug delivery. Current Opinion in Colloid & Interface Science, 16(3), 182-194. http://dx.doi.org/10.1016/j.cocis.2010.10.003.

24. Ribeiro, M. E. N. P., Moura, C. L., Vieira, M. G. S., Gramosa, N. V., Chaibundit, C., Mattos, M. C., Attwood, D., Yeates, S. G., Nixon, S. K., & Ricardo, N. M. P. S. (2012). Solubilisation capacity of Brij surfactants. International Journal of Pharmaceutics, 436(1-2), 631-635. http://dx.doi.org/10.1016/j.ijpharm.2012.07.032. PMid:22842626.
588371c67f8c9d0a0c8b4a64 polimeros Articles
Links & Downloads

Polímeros: Ciência e Tecnologia

Share this page
Page Sections