Polímeros: Ciência e Tecnologia
https://revistapolimeros.org.br/article/doi/10.1590/0104-1428.1756
Polímeros: Ciência e Tecnologia
Scientific & Technical Article

Avaliação da Goma Guar no desenvolvimento de comprimidos matriciais de liberação controlada de teofilina

Evaluation of Guar Gum in the development of theophylline controlled-release matrix tablets

Oliveira, Edilene Gadelha de; Campos, Rosana de Sousa; Machado, Anaiara Silva; Pereira, Juliana Fernandes; Araújo, Tamara Gonçalves de

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Resumo

O objetivo desse estudo foi formular e avaliar comprimidos de liberação controlada. Comprimidos de liberação controlada de teofilina foram preparadas pelo método de compressão direta usando dois polímeros como, o HPMC K 100M (polímero hidrofílico) e a Goma Guar (Polímero natural), isolado ou em mistura (GG:HPMC 3:1) e GG:HPMC 1:3). Os comprimidos foram caracterizados através do peso médio, diâmetro, altura, dureza, friabilidade. Todos os resultados estiveram em conformidade com os limites aceitáveis. O ensaio de intumescimento foi realizado em água destilada durante 4 horas, sendo determinado pela diferença de peso do comprimido seco e intumescido. O ensaio de dissolução foi realizado em água destilada (900 mL, 37 ± 0,5ºC, 50 rpm, aparato II) durante 8 horas. Os resultados demonstraram que a Goma guar isolada não possui capacidade de retardar a liberação da teofilina por 8 horas. Comprimidos matriciais contendo GG:HPMC (3:1) apresentaram um melhor controle de liberação da teofilina.

Palavras-chave

Goma Guar, teofilina, comprimidos, liberação controlada.

Abstract

Guar gum (GG) has been widely used in drug delivery systems due to its low cost and nontoxicity. Theophylline controlled release tablets were prepared by directly compressed method using two polymers such as HPMC K 100M (hydrophilic polymer) and Guar Gum (natural polymer), isolated or in mixture (GG:HPMC 3:1 and GG:HPMC 1:3). The formulated tablets were evaluated for: weight variation, diameter, height, hardness and friability. All the parameters were within the acceptable limits. The swelling test was performed in distilled water for 4 hours, it was determined by the difference in weight of the dry and swollen tablet. The dissolution test was performed in distilled water (900 mL, 37 ± 0.5ºC, 50 rpm, apparatus II) for 8 hours. The results showed that guar gum alone could not control the theophylline release effectively for 8 hours. Matrix tablet prepared from GG: HPMC (3:1) is a better formulation for the sustained released matrix tablets of theophylline.

Keywords

Guar Gum, theophylline, tablets, controlled release.

References

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