Polímeros: Ciência e Tecnologia
https://revistapolimeros.org.br/doi/10.1590/S0104-14282011005000061
Polímeros: Ciência e Tecnologia
Review Article

Polímeros Usados como Sistemas de Transporte de Princípios Ativos

Polymers for Drug Delivery Systems Formulations

Severino, Patrícia; Santana, Maria Helena A.; Malmonge, Sonia M.; Souto, Eliana B.

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Resumo

Os diferentes sistemas de transporte têm evidenciado potencial terapêutico para uma grande variedade de princípios ativos, satisfazendo vários requisitos, como a prevenção da sua eliminação rápida do organismo, a redução da sua toxicidade sistêmica, a estabilização e a otimização do seu metabolismo, e o direcionamento específico ao local alvo e os mecanismos de defesa. No entanto, têm sido reconhecidos vários outros desafios associados à liberação específica do princípio ativo ao local alvo, pelo que, para ultrapassar os obstáculos químicos e biológicos, a seleção do polímero utilizado para a preparação do sistema de transporte é de importância crucial. O presente trabalho apresenta um relato sobre os principais polímeros naturais e sintéticos utilizados para a preparação de sistemas de transporte de princípios ativos in vivo

Palavras-chave

Polímeros sintéticos, polímeros naturais, transporte de princípios ativos

Abstract

The different carrier systems have shown therapeutic potential for a wide variety of drugs, satisfying multiple requirements, such as prevention of rapid elimination, reducing toxicity, promoting stabilization, optimization of metabolism, drug delivery and defense mechanisms. However, it has been recognized several other challenges associated with the specific release of actives in drug delivery. Therefore, to overcome chemical and biological obstacles, the selection of the polymer used to prepare the transport system is crucial. This paper presents a report on the main natural and synthetic polymers used in the preparation of drug carrier systems in vivo.

Keywords

Synthetic polymers, natural polymers, carrier of drugs

References

1. Parmar, J.J.; Singh, D.J.; Hegde, D.D.; Lohade, A.A.; Soni, P.S.; Samad, A. & Menon, M.D. -Indian J. Pharm. Sci.,72, p.442 (2010).

2. Valero, M.; Perez-Revuelta, B.I. & Rodriguez, L.J. - Int. J. Pharm.,6, p.97 (2003). http://dx.doi.org/10.1016/S0378-5173(02)00664-6

3. Karavelidis, V.; Giliopoulos, D.; Karavas, E. &Bikiaris, D. - Eur. J. Pharm. Sci.,23, p.636 (2010).PMid:20863892. http://dx.doi.org/10.1016/j. ejps.2010.09.004

4. Men, K.;Zeng, S.; Gou, M.; Guo, G.; Gu, Y.C.; Luo, F.; Zhao, X.;Wei, Y. &Qian, Y. - J. Biomed. Nanotechnol.,6, p.292 (2010).

5. Aji Alex, M.R.; Chacko, A.J.; Jose, S. &Souto, E.B. - J. Pharm. Sci., 18, p.11 (2010).

6. Midhun, B.T.; Shalumon, K.T.; Manzoor, K.; Jayakumar, R.; Nair, S.V. &Deepthy, M. J. - Biomater. Sci. Polym. (2010) In press.

7. Kang, J.W.; Davaa, E.; Kim, Y.T. & Park, J.S. - J. Drug Target., 18, p.637 (2010).PMid:20192816. http://dx.doi. org/10.3109/10611861003649712

8. Zhang, P.; Chen, L.; Zhang, Z.; Lin, L. & Li, Y. - J. Nanosci. Nanotechnol.,10, p.7541 (2010).

9. Naczynski, D.J.; Andelman, T.; Pal, D.; Chen, S.; Riman, R.E.; Roth, C.M. &Moghe, P.V. - Small., 2, p.1631 (2010).PMid:20586056. http:// dx.doi.org/10.1002/smll.200902403

10. Xiong, S.; Yu, B.; Wu, J.; Li, H. & Lee, R.J. - Biomed. Pharmacother. (2010).In press.

11. Jose, S.; Prema, M.T.; Chacko, A.J.; Thomas, A.C. &Souto, E.B. - Colloids Surf. B Biointerfaces. (2010) In press.

12. Cun, D.; Foged, C.; Yang, M.; Frokjaer, S. & Nielsen, H.M. - Int. J. Pharm., 5, p.70 (2010).PMid:19836438. http://dx.doi.org/10.1016/j. ijpharm.2009.10.023

13. Chan, A.W. & Neufeld, R.J. - Biomaterials, 34, p.9040 (2010). PMid:20739057. http://dx.doi.org/10.1016/j.biomaterials.2010.07.111

14. Liu, J.; Qiu, Z.; Wang, S.; Zhou, L. & Zhang, S. - Biomed. Mater., 6, p.065002 (2010).PMid:20924138. http://dx.doi.org/10.1088/1748- 6041/5/6/065002

15. Akiba, I.;Terada, N.; Hashida, S.; Sakurai, K.; Sato, T.; Shiraishi, K.; Yokoyama, M.; Masunaga, H.; Ogawa, H.; Ito, K. & Yagi, N. - Langmuir, 10, p.7544 (2010).PMid:20361731. http://dx.doi. org/10.1021/la904355p

16. Lao, L.L.; Peppas, N.A.; Boey, F.Y. &Venkatraman, S.S. - Int. J. Pharm. (2010). In press.

17. Raval, J.A.; Patel, J.K. & Patel, M.M. - Acta Pharm., 4, p.455 (2010). PMid:21169137. http://dx.doi.org/10.2478/v10007-010-0034-7

18. Ramtoola, Z.; Lyons, P.; Keohane, K.; Kerrigan, S.W.; Kirby, B.P. & Kelly, J.G. - J. Pharm. Pharmacol., 1, p.26 (2010).

19. He, C.; Hu, Y.; Yin, L.; Tang, C. & Yin, C. - Biomaterials, 13, p.3657(2010). PMid:20138662. http://dx.doi.org/10.1016/j.biomaterials.2010.01.065

20. Oliveira, R.B. & Lima, E.M. - Rev. Brasileira de fármacia, 3, p.29‑35(2006).

21. Severino, P.; Dalla Costa, T.C.; Silva, H.; Souto, E.B. & Santana, M.H.A. - J. Pharm. Biom. Anal. Submetido.

22. Yeh, M.K.; Chen, J.L.; Chiang, C.H. & Chang, Z.Y. - J. Microencapsul.,24, p.82 (2007). PMid:17438944. http://dx.doi. org/10.1080/02652040601058533

23. Jones, O.G. &McClements, D.J. - Adv. Colloid Interface Sci. (2010). In press.

24. Ulbrich, K.; Hekmatara, T.; Herbert, E. & Kreuter J. - Eur. J. Pharm. Biopharm.,71, p.251 (2009). PMid:18805484. http://dx.doi. org/10.1016/j.ejpb.2008.08.021

25. Ulbrich, K.; Michaelis, M.; Rothweiler, F.; Knobloch, T.; Sithisarn, P.; Cinatl, J. &kreuter, J. - Int. J. Pharm. (2010). In press.

26. Yamada, K.; Yamamoto, N.; Yamada, Y.; Mukohara, T.; Minami, H. & Tamura, T. - Jpn J. Clin. Oncol.,40, p.404 (2010).PMid:20133335. PMCid:2862657. http://dx.doi.org/10.1093/jjco/hyp19227. Elsadek, B.; Graeser, R.; Esser, N.; Schäfer-Obodozie, C.; Tsurumi, C.; Abu Ajaj, K.; Warnecke, A.; Unger, C.; Saleem, T. &Kratz, F. - Prostate Cancer Prostatic Dis., 14, p.14 ( 2011).PMid:21042336. http://dx.doi. org/10.1038/pcan.2010.43

28. Kim, T.H.; Jiang, H.H.; Youn, Y.S.; Park, C.W.; Tak, K.K.; Lee, S.; Kim, H.; Jon, S.; Chen, X. & Lee, K.C. - Int. J. Pharm., 403, p.403 (2011).

29. Guo, L.; Peng, Y.; Yao, J.; Sui, L.; Gu, A. & Wang, J. - Cancer. Biother.Radiopharm., 25, p.471 (2010). http://dx.doi.org/10.1089/ cbr.2009.0724

30. Katti, D. &Krishnamurti, N. - J. Microencapsul., 16, p.231 (1999). PMid:10080116. http://dx.doi.org/10.1080/026520499289202

31. Yu, N.Y.; Schindeler, A.; Little, D.G. &Ruys, A.J. - J. Biomed. Mater. Res. B Appl. Biomater., 93, p.285 (2010).

32. Sengupta, D. &Heilshorn, S.C. - Tissue Eng. Part B Rev., 16, p.285 (2010).PMid:20141386. http://dx.doi.org/10.1089/ten.teb.2009.0591

33. Md, S.; Ahuja, A.; Khar, R.K.; Baboota, S.; Chuttani, K.; Mishra, A.K. & Ali, J. - Drug. Deliv. (2010). In press.

34. Vader, P.; Van der Aa, L.J.; Engbersen, J.F.; Storm, G. &Schiffelers, R.M. - Pharm. Res. (2010). In press.

35. Barakat, N.S. &Almurshedi, A.S. - J. Microencapsul. (2010). In press.

36. Brandt, F.; Bank, D.; Cross, S.L. & Weiss, R. - Dermatol. Surg.,36, p.1876 (2010).PMid:20969665. http://dx.doi.org/10.1111/j.1524- 4725.2010.01777.x

37. Akinlade, B.; Elkordy, A.A.; Essa, E.A. &Elhagar, S. - Sci. Pharm., 78, p.325 (2010).PMid:21179350. PMCid:3002790. http://dx.doi. org/10.3797/scipharm.0912-23

38. Bagchi, S.; Li, W. &Plakogiannis F. - Pharm. Dev. Technol. (2011). In press.

39. Zhang, L.; Chai, G.; Zeng, X.; He, H.; Xu, H. & Tang X. - Drug Dev. Ind. Pharm., 36, p.1054 (2010).PMid:20818965. http://dx.doi. org/10.3109/03639041003642081

40. Patel, M.M. & Amin, A.F. - Drug Deliv. 2010. In press.

41. Aguilar-de-Leyva, A.; Sharkawi, T.; Bataille, B.; Baylac, G. &Caraballo, I.- Int. J. Pharm., 14, p.133 (2011).PMid:21094234. http:// dx.doi.org/10.1016/j.ijpharm.2010.11.024

42. Vaghani, S.S.; Patel, S.G.; Jivani, R.R.; Jivani, N.P.; Patel, M.M. &Borda, R. - Pharm. Dev. Technol. (2010).In press.

43. Dalmoro, A.; Lamberti, G.; Titomanlio, G.; Barba, A.A. &D’Amore, M. - AAPS PharmSciTech., 11, p.1500 (2010).PMid:20931307. PMCid:3011076. http://dx.doi.org/10.1208/s12249-010-9528-3

44. Notara, M.; Scotchford, C.A.; Grant, D.M.; Weston, N. & Roberts, G.A. - J. Biomed. Mater. Res. A, 89, p.854 (2009).PMid:18465818. http://dx.doi.org/10.1002/jbm.a.32027

45. Pescosolido, L.; Vermonden, T.; Malda, J.;Censi, R.; Dhert, W.J.;Alhaique, F.; Hennink, W.E. &Matricardi, P. - ActaBiomater. (2010). In press.

46. Fang, A. &Cathala, B. - Colloids Surf. B Biointerfaces., 82, p.81 (2010). PMid:20833004. http://dx.doi.org/10.1016/j.colsurfb.2010.08.020

47. Moroni, A.; Drefko, W. & Thone, G. - Drug Dev. Ind. Pharm., 37, p.216 (2010).PMid:20973612. http://dx.doi.org/10.3109/03639045.2010.504 726

48. Belgamwar, V.S. &Surana, S.J. - Chem. Pharm. Bull., 58, p.1168 (2010). http://dx.doi.org/10.1248/cpb.58.1168

49. Zhang, W. & He, X. - J. Biomech. Eng., 131, p.074515 (2009). PMid:19640151. http://dx.doi.org/10.1115/1.3153326

50. Lin, C. &Engbersen, J.F. - J. Control. Release.,132, p.267 (2008). PMid:18655813. http://dx.doi.org/10.1016/j.jconrel.2008.06.022

51. Kroencke, T.J.; Scheurig, C.; Lampmann, L.E.; Boekkooi, P.F.; Kissner, L.; Kluner, C.; Weichert, W.; Hamm, B. &Lohle, P.N. - J. Vasc. Interv. Radiol., 19, p.47, 2008.PMid:18192467. http://dx.doi.org/10.1016/j. jvir.2007.08.019

52. Marino, M.T.; Costello, D.; Baughman, R.; Boss, A.; Cassidy, J.; Damico C, Van Marle, S.; Van Vliet, A. & Richardson, P.C. - Clin. Pharmacol.Ther., 88, p.243 (2010). http://dx.doi.org/10.1038/ clpt.2010.85

53. Bhise, K.S.; Dhumal, R.S.; Shailesh, B.; Paradkar, A.R. &Kadam, S.S. - AAPS PharmSciTech., 11, p.226, 2010.PMid:20131020. PMCid:2850499. http://dx.doi.org/10.1208/s12249-010-9379-y

54. Calvo, P.; Remunan-Lopez, C.; Vila-Jato, J.L. & Alonso, M.J. - Pharm. Res., 14, p.1431 (1997).PMid:9358557. http://dx.doi. org/10.1023/A:1012128907225

55. El-Leithy, E.S.; Shaker, D.S.; Ghorab, M.K. & Abdel-Rashid, R.S. - AAPS PharmSciTech., 11, p.1695 (2010).PMid:21108027. http:// dx.doi.org/10.1208/s12249-010-9544-356. Angadi, S.C.; Manjeshwar, L. S. &Aminabhavi, T.M. - Int. J. Biol. Macromol.,47, p.171 (2010). PMid:20471411. http://dx.doi.org/10.1016/j.ijbiomac.2010.05.003

57. Brannon Peppas, L. - Int. J. Pharm., 116, p.1 (1995).

58. Qiu, L.Y. & Bae, Y.H. - Pharm. Res., 23, p.1 (2006).PMid:16392022. http://dx.doi.org/10.1007/s11095-005-9046-2

59. Singh, S. -J. Nanosci. Nanotechnol., 10, p.7906 (2010).

60. Picos, D. R.; Carril, M.G. & Mena, D.F. Rev. Cubana Farm.,34, p.70 (2000).

61. Khandare, J. & Haag, R. - Handb. Exp. Pharmacol., 197, p.221 (2010). PMid:20217532. http://dx.doi.org/10.1007/978-3-642-00477-3_8

62. Jain, J.P.; Modi, S. & Kumar, N. - J. Biomed. Mater. Res. A., 84, p.740 (2008). PMid:17635032. http://dx.doi.org/10.1002/jbm.a.31456

63. Jain, J.P.; Chitkara, D. & Kumar, N. - Expert. Opin. Drug Deliv., 5, p.889 (2008). PMid:18712998. http://dx.doi.org/10.1517/17425247.5.8.889

64. Tamargo, R.J.; Epstein, J.I.; Reinhard, C.S.; Chasin, M. & Brem, H. - J. Biomed. Mater. Res., 23, p.253 (1989).PMid:2708412. http://dx.doi. org/10.1002/jbm.820230209

65. Brem, H.; Kader, A.; Epstein, J.I.; Tamargo, R.J.; Domb, A.; Langer, R.; Leong, K.W. - Sel. Cancer Ther., 5, p.55 (1989).PMid:2772427. http://dx.doi.org/10.1089/sct.1989.5.55

66. Carrillo-Conde, B.; Garza, A.; Anderegg, J. & Narasimhan, B. - J. Biomed. Mater. Res. A., 95, p.40 (2010).PMid:20740599. http://dx.doi. org/10.1002/jbm.a.32815

67. Lee, W.C. & Chu, I.M. - J. Biomed. Mater. Res. B Appl. Biomater., 84, p.138, 2008.

68. Gopferich, A. &Tessmar, J. - Adv. Drug Deliv. Rev., 54, p.911 (2002).

69. Dang, W., Daviau, T. & Brem, H. - Pharm. Res., 13, p.683 (1996). PMid:8860422. http://dx.doi.org/10.1023/A:1016035229961

70. Katti, D.S.; Lakshmi, S.; Langer, R. & Laurencin, C.T. - Adv. Drug Deliv. Rev., 54, p.933 (2002). http://dx.doi.org/10.1016/S0169- 409X(02)00052-2

71. Kipper, M.J.; Wilson, J.H.; Wannemuehler, M.J. & Narasimhan, B. - J. Biomed. Mater. Res. A., 76, p.798 (2006).PMid:16345084. http:// dx.doi.org/10.1002/jbm.a.30545

72. Gao, J.; Niklason, L. & Zhao, X.M. Langer R. - J. Pharm. Sci., 87, p.246 (1998).PMid:9519161. http://dx.doi.org/10.1021/js970284u

73. Yang, Y.; Xu, Z.; Chen, S.; Gao, Y.; Gu, W.; Chen, L.; Pei, Y. & Li, Y. - Int. J. Pharm., 353, p.277 (2008). http://dx.doi.org/10.1016/j. ijpharm.2007.11.041

74. Schacht, E.; Vandorpe, J.; Dejardin, S.; Lemmouchi, Y. & Seymour, L. - Biotechnol. Bioeng., 52, p.102 (1996). http://dx.doi. org/10.1002/(SICI)1097-0290(19961005)52:1%3C102::AIDBIT10% 3E3.3.CO;2-B

75. Giavaresi, G.; Tschon, M.; Borsari, V.; Daly, J.H.; Liggat, J.J.; Fini, M.; Bonazzi, V.; Nicolini, A.; Carpi, A.; Morra, M.; Cassinelli, C. & Giardino, R. - Biomed. Pharmacother., 58, p.411 (2004). http://dx.doi. org/10.1016/S0753-3322(04)00111-8

76. Kawakami, H.; Kanezaki, S.; Sudo, M.; Kanno, M.; Nagaoka, S. & Kubota, S. - Artif. Organs., 26, p.883 (2002).PMid:12296930. http:// dx.doi.org/10.1046/j.1525-1594.2002.07029.x

77. Chang, Y.; Bender, J.D.; Phelps, M.V. & Allcock, H.R. - Biomacromolecules., 3, p.1364 (2002).PMid:12425677. http://dx.doi. org/10.1021/bm020087b

78. Allcock, H.R.; Steely, L.B.; Kim, S.H.; Kim, J.H. & Kang, B.K. - Langmuir., 23, p.8103 (2007).PMid:17590030. http://dx.doi. org/10.1021/la700840j

79. Veronese, F.M.; Marsilio, F.; Caliceti, P.; De Filippis, P.; Giunchedi, P. & Lora, S. - J. Control. Release., 52, p.227 (1998). http://dx.doi. org/10.1016/S0168-3659(97)00098-9

80. Caliceti, P.; Veronese, F.M. & Lora S. - Int. J. Pharm., 211, p.57 (2000). http://dx.doi.org/10.1016/S0378-5173(00)00588-3

81. Chao, P.; Deshmukh, M.; Kutscher, H.L.; Gao, D.; Rajan, S.S.; Hu, P.; Laskin, D.L.; Stein, S. & Sinko, P.J. - Anticancer Drugs., 21, p.65 (2010). PMid:19966540. http://dx.doi.org/10.1097/CAD.0b013e328332a322

82. Sakuma, S.; Sudo, R.; Suzuki, N.; Kikuchi, H.; Akashi, M. & Hayashi, M. - Int. J. Pharm., 177, p.161 (1999). http://dx.doi.org/10.1016/ S0378-5173(98)00346-9

83. Dunn, S.E.; Brindley, A.; Davis, S.S.; Davies, M.C. &Illum, L. - Pharm. Res., 11, p.1016 (1994).PMid:7937542. http://dx.doi. org/10.1023/A:1018939521589

84. Moghimi, S.M.; Porter, C.J.; Muir, I.S.; Illum, L. & Davis, S.S. - Biochem. Biophys. Res. Commun., 177, p.861 (1991). http://dx.doi. org/10.1016/0006-291X(91)91869-E

85. Gbadamosi, J.K.; Hunter, A.C. &Moghimi, S.M. - FEBS Lett., 532, p.338 (2002). http://dx.doi.org/10.1016/0006-291X(91)91869-E

86. Ghassemi, A.H.; Van Steenbergen, M.J.; Talsma, H.; Van Nostrum, C.F.; Crommelin, D.J. &Hennink, W.E. - Pharm. Res., 27, p.2008(2010).PMid:20602152. PMCid:2916118. http://dx.doi.org/10.1007/ s11095-010-0205-8

87. Choudhury, A.; Das, S.; Bahadur, S.; Saha, S. & Roy, A. - Indian J. Pharm. Sci., 72, p.491 (2010).PMid:21218061. PMCid:3013562. http://dx.doi.org/10.4103/0250-474X.73922

88. Kriwet, B.; Walter, E. & Kissel, T. - J. Control. Release., 56, p.149 (1998). http://dx.doi.org/10.1016/S0168-3659(98)00078-9

89. Madhusudhan, S.; Panda, A.K.; Parimalakrishnan, S.; Manavalan, R. & Manna, P.K. - J. Microencapsul., 27, p.281 (2010). PMid:20515261. http://dx.doi.org/10.3109/02652040903131319

90. Das, S.; Suresh, P.K. & Desmukh, R.- Nanomedicine., 6, p.318 (2010).PMid:19800990. http://dx.doi.org/10.1016/j.nano.2009.09.002

91. Jelvehgari, M.; Barar, J.;Valizadeh, H.; Shadrou, S. &Nokhodchi, A. - Pharm. Dev. Technol., 19, (2010).In press.

92. Ahuja, M.; Dhake, A.S.; Sharma, S.K. &Majumdar, D.K. - J. Microencapsul., 28, p.37 (2010).PMid:21171815. http://dx.doi.org/10. 3109/02652048.2010.523794

93. Voltan, R.; Castaldello, A.; Brocca-Cofano, E.; Altavilla, G.; Caputo, A.; Laus, M.;Sparnacci, K.; Ensoli, B.; Spaccasassi, S.; Ballestri, M. & Tondelli, L.- Pharm. Res., 24, p.1870 (2007).PMid:17476465. http:// dx.doi.org/10.1007/s11095-007-9310-8

94. Fundueanu, G.; Mocanu, G.; Constantin, M.; Carpov, A.; Bulacovschi, V.; Esposito, E. & Nastruzzi C. - J. Pharm., 218, p.13 (2001).

95. Fundueanu, G.; Constantin, M.; Bortolotti, F.; Ascenzi, P.; Cortesi, R. & Menegatti, E. - Macromol. Biosci.,5, p.955 (2005). PMid:16211551. http://dx.doi.org/10.1002/mabi.200500099

96. Cameron, D.J. & Shaver M. P.- Chem. Soc. Rev. (2010). In press.

97. Pang, X.; Zhuang, X.; Tang, Z. & Chen, X. - Biotechnol. J., 5, p.1125 (2010).PMid:21058315. http://dx.doi.org/10.1002/biot.201000135

98. Knight, P.T.; Kirk, J.T.; Anderson, J.M. & Mather P. T. - J. Biomed. Mater. Res. A., 94, p.333 (2010).

99. Lukaszczyk, J.; Jaszcz, K. & Srichana, T. - J. Biomater. Sci. Polym., 21, p.691 (2010).PMid:20482978. http://dx.doi. org/10.1163/156856209X435826

100. Han, S.I.; Yoo, Y.; Kim, D.K. & Im, S.S. - Macromol. Biosci., 15, p.200 (2004).

101. Liu, J.W.; Zhao, Q. & Wan, C.X. - Space Med. Med. Eng., 14, p.308 (2001).

102. Albertsson, A.C. & Varma, I.K. - Biomacromolecules, 4, p.1466 (2003).PMid:14606869. http://dx.doi.org/10.1021/bm034247a

103. Diaz, R.V.; Llabres, M. &Evora, C. - J. Control. Release.,59, p.55 (1999). http://dx.doi.org/10.1016/S0168-3659(98)00179-5

104. Voronov, A.; Vasylyev, S.; Kohut, A. &Peukert, W. - J. Colloid Interface Sci., 15, p.323 (2008).

105. Gorna, K. & Gogolewski, S. - J. Biomed. Mater. Res., 60, p.592 (2002). PMid:11948518. http://dx.doi.org/10.1002/jbm.10100

106. Xiao, R.Z.; Zeng, Z.W.; Zhou, G.L.; Wang, J.J.; Li, F.Z. & Wang, A.M. - Int. J. Nanomedicine., 5, p.1057 (2010).

107. Santra, S.; Kaittanis, C. & Perez, J.M. - Langmuir., 26, p.5364 (2010).PMid:19957939. PMCid:2854188. http://dx.doi.org/10.1021/ la9037843

108. Klapper, M.; Nenov, S.; Haschick, R.; Muller, K. & Mullen, K. - Acc. Chem. Res., 41, p.1190 (2008).PMid:18759463. http://dx.doi. org/10.1021/ar8001206

109. Witt, C. & Kissel, T. - Eur. J. Pharm. Biopharm.,51, p.171 (2001). http://dx.doi.org/10.1016/S0939-6411(01)00130-8
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