Polímeros: Ciência e Tecnologia
https://revistapolimeros.org.br/article/doi/10.4322/polimeros.2013.088
Polímeros: Ciência e Tecnologia
Scientific & Technical Article

Preparation of Poly(Urethane-urea) Nanoparticles Containing Açaí Oil by Miniemulsion Polymerization

Valério, Alexsandra; Araújo, Pedro H. H.; Sayer, Claudia

Downloads: 1
Views: 1200

Abstract

Polyurethane nanoparticles (NPs) are promising candidates for the controlled and targeted delivery of therapeutics in a variety of biomedical applications. In this work, a report is made of NPs produced by miniemulsion polymerization with isophorone diisocyanate (IPDI) and castor oil, glycerol, and poly(ethylene glycol) (PEG) with molar masses 400 and 1000 as monomers and Tween 80, Span 80 and Lutensol AT 25 as surfactant and açaí oil as costabilizer. Stable dispersions with sizes between 100 - 500 nm were achieved. The effects from polyol, types and concentration of surfactant and reaction temperature on the size of the NPs and weight average molar mass were evaluated. Morphological characterization was accomplished using images from Transmission Electron Microscopy (TEM) and Scanning Electron Microscope (SEM).

Keywords

Miniemulsion polymerization, poly(urea-urethane), açaí oil

References



1. Ding, B. M.; He, X.; Wang, Z.; LI, J.; Tan, H.; Fu, Q. & Gu, Q. – Biomaterials, 32, p.9515 (2011). http://dx.doi. org/10.1016/j.biomaterials.2011.08.074

2. Souto, E. B.; Severino, P.; Santana, M. H. A. – Polímeros, 22, p.96 (2012). http://dx.doi.org/10.1590/ S0104-14282012005000006

3. Zanetti-Ramos, B. G.; Fritzen-Garcia, M. B.; De Oliveira, C. S.; Pasa, A. A.; Soldi, V.; Borsali, R. & Pasa, T. B. C. - Mat. Sci. and Eng: C, 29, p.638 (2009). http://dx.doi. org/10.1016/j.msec.2008.10.040

4. Gaudin, F. & Sintes-Zydowicz, N. Col. - Surf. A: Phys. Eng. Asp., 331, p.133 (2008). http://dx.doi.org/10.1016/j. colsurfa.2008.07.028

5. Torini, L.; Argillier, J. F. & Zydowicz, N. – Macromolecules, 38, p.3225, (2005). http://dx.doi. org/10.1021/ma047808e

6. Gaudin, F. & Sintes-Zydowicz, N. – Col. Surf. A: Phys. Eng. Asp., 384, p.698, (2011). http://dx.doi.org/10.1016/j. colsurfa.2011.05.050

7. Jabbari, E. & Khakpour, M. – Biomaterials, 21, p.2073 (2000). http://dx.doi.org/10.1016/S0142-9612(00)00135-6

8. Bouchemal, K.; Briançon, S.; Perrier, E.; Fessi, H.; Bonnet, I. & Zydowicz, N. – Inter. J. Phar., 269, p.89, (2004). http:// dx.doi.org/10.1016/j.ijpharm.2003.09.025

9. Zanetti-Ramos, B. G.; Lemos-Senna, E.; Soldi, V.; Borsali, R.; Cloutet, E. & Cramailh, P. – Polymer, 47, p.8080, (2006). http://dx.doi.org/10.1016/j.polymer.2006.09.057

10. Antonietti, M. & Landfester, K. – Polym. Sci., 27, p.689 (2002).

11. Asua, J. M. – Progr. Polym. Sci., 27, p. 1283 (2002). http:// dx.doi.org/10.1016/S0079-6700(02)00010-2

12. El-Aasser, M. S. & Sudol, E. D. - J. C. T. Res., 1, p. 21 (2004).

13. Tiarks, F. & Landfester, K. – J. Pol. Sci. A: Pol. Chem., 39, p.2520, (2001). http://dx.doi.org/10.1002/pola.1228

14. Barrére, M. & Landfester, K. – Macromolecules, 36, p.5119, (2003). http://dx.doi.org/10.1021/ma025981+

15. Zhang, Q.; Shi, Y.; Zhan, X. & Chen, F. - Col. Surf. A: Phys. Eng. Asp. 393, p.17, (2012). http://dx.doi.org/10.1016/j. colsurfa.2011.10.016

16. Coutinho, F. M. B.; Delpech, M. C.; Alves, T. L. & Gomes, A. S. – Polímeros, 12, p.248, (2002). http://dx.doi. org/10.1590/S0104-14282002000400007

17. Nascimento, R. J. S.; Couri, S.; Antoniassi, R. & Freitas, S. P. - Ver. Bras. Frutic., 30, p.498, (2008). http://dx.doi. org/10.1590/S0100-29452008000200040

18. Machado, A. C. H. R. – “Desenvolvimento e avaliação da incorporação e liberação de óleo de açaí em hidrogéis de poli(N-vinil-2-pirrolidona)”, Dissertação de Mestrado, Instituto de Pesquisas Energéticas e Nucleares (2010).

19. Narine, S. S. & Kong, X. - “Bailey’s Industrial Oil and Fat Products”, Wiley, (2005).

20. Rosen, M. J. - “Surfactants and Interfacial Phenomena”, Wiley-Interscience, New York (2004). http://dx.doi. org/10.1002/0471670561
588371977f8c9d0a0c8b498d polimeros Articles
Links & Downloads

Polímeros: Ciência e Tecnologia

Share this page
Page Sections