Binary mixture micellar systems of F127 and P123 for griseofulvin solubilisation
Dutra, Lillian Maria Uchôa; Ribeiro, Maria Elenir Nobre Pinho; Cavalcante, Igor Marques; Brito, Débora Hellen Almeida de; Semião, Luana de Moraes; Silva, Raquel Freitas da; Fechine, Pierre Basílio Almeida; Yeates, Stephen George; Ricardo, Nágila Maria Pontes Silva
http://dx.doi.org/10.1590/0104-1428.1831
Polímeros: Ciência e Tecnologia, vol.25, n5, p.433-439, 2015
Abstract
Pluronics® molecules self-assemble in aqueous solution providing a core/shell architecture that improves the solubility of hydrophobic drugs. Binary mixtures of Pluronics® have been studied as drug nanocarriers in order to combine their advantages, like high colloidal stability, small particle size and good solubilisation capacity (Scp). In this work we studied Pluronics® binary mixture, P123 and F127, as nanocarriers of the hydrophobic drug griseofulvin. P123 (E21P67E21) shows a relative good Scp, whereas F127 (E98P67E98) shows a good colloidal stability. According to data, these binary mixtures form stables nano-sized comicelles in aqueous solution. The Scp of the P123/F127 systems at 25 and 37 °C was monitored by UV/Visible spectroscopy, showing good results at both temperatures, as would be expected, since P123/F127 have similar length hydrophobic block. Hydrophobic-dependence and temperature-responsive of the systems were evaluated by CMC, particle size and colloidal stability. Hence, stables P123/F127 comicelles may have potencial as hydrophobic drug delivery
Keywords
binary mixtures, griseofulvin, Pluronics.
References
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2. Mora-Huertas, C. E., Fessi, H., & Elaissari, A. (2010). Polymer-based nanocapsules for drug delivery. International Journal of Pharmaceutics, 385(1-2), 113-142. http://dx.doi.org/10.1016/j.ijpharm.2009.10.018. PMid:19825408.
3. Xiong, X.-B., Falamarzian, A., Garg, S. M., & Lavasanifar, A. (2011). Engineering of amphiphilic block copolymers for polymeric micellar drug and gene delivery. Journal of Controlled Release, 155(2), 248-261. http://dx.doi.org/10.1016/j.jconrel.2011.04.028. PMid:21621570.
4. Elluru, M., Ma, H., Hadjiargyrou, M., Hsiao, B. S., & Chu, B. (2013). Synthesis and characterization of biocompatible hydrogel using Pluronics-based block copolymers. Polymer, 54(8), 2088-2095. http://dx.doi.org/10.1016/j.polymer.2013.02.017.
5. Jindal, N., & Mehta, S. K. (2015). Nevirapine loaded Poloxamer 407/Pluronic P123 mixed micelles: optimization of formulation and in vitro evaluation. Colloids and Surfaces B: Biointerfaces, 129, 100-106. http://dx.doi.org/10.1016/j.colsurfb.2015.03.030.
6. Kadam, Y., Yerramilli, U., Bahadur, A., & Bahadur, P. (2011). Micelles from PEO-PPO-PEO block copolymers as nanocontainers for solubilization of a poorly water soluble drug hydrochlorothiazide. Colloids and Surfaces B: Biointerfaces, 83(1), 49-57. http://dx.doi.org/10.1016/j.colsurfb.2010.10.041. PMid:21123038.
7. Zhang, W., Shi, Y., Chen, Y., Ye, J., Sha, X., & Fang, X. (2011). Multifunctional Pluronic P123/F127 mixed polymeric micelles loaded with paclitaxel for the treatment of multidrug resistant tumors. Biomaterials, 32(11), 2894-2906. http://dx.doi.org/10.1016/j.biomaterials.2010.12.039. PMid:21256584.
8. Lee, E. S., Oh, Y. T., Youn, Y. S., Nam, M., Park, B., Yun, J., Kim, J. H., Song, H.-T., & Oh, K. T. (2011). Binary mixing of micelles using Pluronics for a nano-sized drug delivery system. Colloids and Surfaces B: Biointerfaces, 82(1), 190-195. http://dx.doi.org/10.1016/j.colsurfb.2010.08.033. PMid:20850281.
9. Zhang, M., Djabourov, M., Bourgaux, C., & Bouchemal, K. (2013). Nanostructured fluids from pluronic® mixtures. International Journal of Pharmaceutics, 454(2), 599-610. http://dx.doi.org/10.1016/j.ijpharm.2013.01.043. PMid:23370436.
10. Alexandridis, P., Holzwarth, J. F., & Hatton, T. A. (1994). Micellization of Poly(ethylene oxide)-Poly(propylene oxide)-Poly(ethylene oxide) triblock copolymers in aqueous solutions: thermodynamics of copolymer association. Macromolecules, 27(9), 2414-2425. http://dx.doi.org/10.1021/ma00087a009.
11. Chaibundit, C., Ricardo, N. M. P. S., Costa, F. D. M. L. L., Yeates, S. G., & Booth, C. (2007). Micellization and gelation of mixed copolymers P123 and F127 in aqueous solution. Langmuir, 23(18), 9229-9236. http://dx.doi.org/10.1021/la701157j. PMid:17676776.
12. Wei, Z., Hao, J., Yuan, S., Li, Y., Juan, W., Sha, X., & Fang, X. (2009). Paclitaxel-loaded Pluronic P123/F127 mixed polymeric micelles: formulation, optimization and in vitro characterization. International Journal of Pharmaceutics, 376(1-2), 176-185. http://dx.doi.org/10.1016/j.ijpharm.2009.04.030. PMid:19409463.
13. Oh, K. T., Bronich, T. K., & Kabanov, A. V. (2004). Micellar formulations for drug delivery based on mixtures of hydrophobic and hydrophilic Pluronic® block copolymers. Journal of Controlled Release, 94(2-3), 411-422. http://dx.doi.org/10.1016/j.jconrel.2003.10.018. PMid:14744491.
14. Rekatas, C. J., Mai, S.-M., Crothers, M., Quinn, M., Collett, J. H., Attwood, D., Heatley, F., Martini, L., & Booth, C. (2001). The effect of hydrophobe chemical structure and chain length on the solubilization of griseofulvin in aqueous micellar solutions of block copoly(oxyalkylene)s. Physical Chemistry Chemical Physics, 3(21), 4769-4773. http://dx.doi.org/10.1039/b107073h.
15. Aliabadi, H. M., & Lavasanifar, A. (2006). Polymeric micelles for drug delivery. Expert Opinion on Drug Delivery, 3(1), 139-162. http://dx.doi.org/10.1517/17425247.3.1.139. PMid:16370946.
16. Ribeiro, M. E. N. P., Vieira, Í. G. P., Cavalcante, I. M., Ricardo, N. M. P. S., Attwood, D., Yeates, S. G., & Booth, C. (2009). Solubilisation of griseofulvin, quercetin and rutin in micellar formulations of triblock copolymers E62P39E62 and E137S18E137. International Journal of Pharmaceutics, 378(1-2), 211-214. http://dx.doi.org/10.1016/j.ijpharm.2009.05.047. PMid:19501147.
17. Zhong, N., Chen, H., Zhao, Q., Wang, H., Yu, X., Eaves, A. M., Sheng, W., Miao, J., Cui, F., & Wang, J. (2010). Effects of griseofulvin on apoptosis through caspase-3- and caspase-9-dependent pathways in K562 leukemia cells: An in vitro study. Current Therapeutic Research, Clinical and Experimental, 71(6), 384-397. http://dx.doi.org/10.1016/S0011-393X(10)80004-9. PMid:24688157.
18. Attwood, D., Booth, C., Yeates, S. G., Chaibundit, C., & Ricardo, N. M. P. S. (2007). Block copolymers for drug solubilisation: Relative hydrophobicities of polyether and polyester micelle-core-forming blocks. International Journal of Pharmaceutics, 345(1-2), 35-41. http://dx.doi.org/10.1016/j.ijpharm.2007.07.039. PMid:17869036.
19. Kulthe, S. S., Inamdar, N. N., Choudhari, Y. M., Shirolikar, S. M., Borde, L. C., & Mourya, V. K. (2011). Mixed micelle formation with hydrophobic and hydrophilic Pluronic block copolymers: Implications for controlled and targeted drug delivery. Colloids and Surfaces B: Biointerfaces, 88(2), 691-696. http://dx.doi.org/10.1016/j.colsurfb.2011.08.002. PMid:21862296.
20. Tadros, T. F. (2005). Applied Surfactants: principles and applications. Weinheim: WILEY-VCH.
21. Kadam, Y., Yerramilli, U., & Bahadur, A. (2009). Solubilization of poorly water-soluble drug carbamezapine in Pluronic® micelles: effect of molecular characteristics, temperature and added salt on the solubilizing capacity. Colloids and Surfaces B: Biointerfaces, 72(1), 141-147. http://dx.doi.org/10.1016/j.colsurfb.2009.03.027. PMid:19403275.
22. Attwood, D., & Booth, C. (2007). Solubilization of a poorly soluble aromatic drug by micellar solutions of amphiphilic block copoly(oxyalkylene)s. In T. F. Tadros (Ed.), Colloid stability and application in pharmacy (pp. 61-78). Weinheim: Wiley-VCH.
23. Attia, A. B. E., Ong, Z. Y., Hedrick, J. L., Lee, P. P., Ee, P. L. R., Hammond, P. T., & Yang, Y.-Y. (2011). Mixed micelles self-assembled from block copolymers for drug delivery. Current Opinion in Colloid & Interface Science, 16(3), 182-194. http://dx.doi.org/10.1016/j.cocis.2010.10.003.
24. Ribeiro, M. E. N. P., Moura, C. L., Vieira, M. G. S., Gramosa, N. V., Chaibundit, C., Mattos, M. C., Attwood, D., Yeates, S. G., Nixon, S. K., & Ricardo, N. M. P. S. (2012). Solubilisation capacity of Brij surfactants. International Journal of Pharmaceutics, 436(1-2), 631-635. http://dx.doi.org/10.1016/j.ijpharm.2012.07.032. PMid:22842626.
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